PGxInsight - Cardiovascular
Millions of Americans currently take cardiovascular medications to treat or prevent heart disease and many have had problems finding the right drug and dose. Over half of all medications, including the majority of heart disease medications, are metabolized by enzymes in the liver. Gene variation is the main factor determining enzyme levels in the liver. If you have too much of the enzyme, you process the medication too quickly: too little of the enzyme and the medication builds up in your bloodstream, potentially causing adverse reactions or side effects. Without knowing your genetics, your physician may need to go through months of trial-and-error prescribing to find the right drug and dose for you.
Tests offered by Retrogen include the CYP2D6, CYP2C9, CYP2C19, VKORC1, SLCO1B1, CYP3A4, CYP3A5, MTHFR, Factor V Leiden, Factor II, and APOE genes. Variation in the Apolipoprotein E gene is associated with increased risk of hyperlipidemia/atherosclerotic vascular disease. Variation in the Factor II and Factor V Leiden genes is associated with increased thrombosis risk. Genetic variants in the MTHFR gene are associated with increased risk of hyperhomocysteinemia. Variation in the SLCO1B1 gene is associated with increased risk of myopathy. Variation in the VKORC1 gene is associated with increased risk of warfarin sensitivity.
||CYP2D6, CYP2C9, CYP2C19, VKORC1, SLCO1B1, CYP3A4, CYP3A5, MTHFR,
Factor V Leiden, Factor II, APOE
||Polymerase Chain Reaction and Sanger Sequencing
||#9002 Cardiovascular Panel
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