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Clinical Diagnostics

PGxInsight - Psychiatric Disorders

Treatment resistance in patients medicated for depression or anxiety is more common than treatment response, and generates significant financial burden. Psychiatric pharmacogenomics improves psychotropic medication treatment by analyzing polymorphisms in genes that affect the metabolism of and response to antidepressant and antipsychotic medications . The International Review of Psychiatry recently published an extensive review validating the clinical use of pharmacogenomic testing to help predict patient response to psychiatric medications and improve treatment outcomes (Altar et al. 2013). The paper provides substantial evidence that psychiatric pharmacogenomic testing has clinical value in predicting how individual patients will tolerate and respond to specific psychiatric medications . The article reviewed published data collected since 2007 examining how DNA sequence variation between individuals affects metabolism and response to medications. The evidence from these studies supports the validity of analyzing patients' genetic profiles to predict the metabolism, safety, and therapeutic efficacy of psychotropic medications commonly used for the treatment of depression, schizophrenia, and bipolar disorder. In psychiatry, about 52% of the psychiatric and 62% of antidepressant or antipsychotic drugs are metabolized by CYP2D6. Tests offered by Retrogen include the CYP2D6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP1A2, OPRM1 and COMT genes.

Available Tests
Psychotropic Panel
Info Sheet  Requisition Form 
Test Information
Genes: CYP2D6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP1A2, OPRM1, COMT, DRD2
Clinical Utility:
Method: Polymerase Chain Reaction and Sanger Sequencing
Test ID: #9003 Cardiovascular Panel
Turn-around Time: 5-8 days
Preferred Specimen: Buccal swabs
CPT Codes: 81479
Billing Information: View Billing Information
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  3. Mulder H, Heerdink ER, van Iersel EE, et al. 2007. Prevalence of patients using drugs metabolized by cytochrome P450 2D6 in different populations: a crosssectional study. Ann Pharmacother. 41:406-413.
  4. Altar CA, Hornberger J, Shewade A, Cruz V, Garrison J, Mrazek D. 2013. Int Rev Psychiatry. Clinical validity of cytochrome P450 metabolism and serotonin gene variants in psychiatric pharmacotherapy. 25:509-33
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