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Clinical Diagnostics

Group B Streptococcus

Group B streptococcus (GBS) infection is the infection caused by the bacterium Streptococcus agalactiae. Group B streptococcal infection can cause serious illness and sometimes death, especially in newborns, the elderly, and people with compromised immune systems. In general, GBS is a harmless commensal bacterium being part of the human microbiota colonizing the gastrointestinal and genitourinary tracts of up to 30% of healthy human adults (asymptomatic carriers).

Vaginal colonization rates range from 4 to 36%, with most studies reporting over 20%. GBS is the main cause of bacterial infections in newborns, such as septicemia, pneumonia, and meningitis, which can lead to death or long-term after effects. Infections in newborns are separated into two clinical types, early-onset disease (EOGBS) and late-onset disease (LOGBS). EOGBS manifests from 0 to 7 living days in the newborn, most of the cases being apparent within 24 hr. LOGBS starts between 7 and 90 days after birth. EOGBS is acquired through exposure of the fetus or baby to GBS from the vagina either in utero or during birth.

Available Tests
Group B streptococcus Panel
Info Sheet  Requisition Form 
Test Information
Organism List: Staphylococcus agalactiae
Clinical Utility: Retrogen offers early & accurate detection, rapid turnaround times, and only requires a single, non-invasive sample collection. Your referring physician will be provided with a detailed, comprehensive report that leads to actionable decisions and forward treatment options.
Method: Retrogen carries out real-time molecular PCR on DNA extracted from vaginal swabs to screen for microorganisms. This quantitative approach uses TaqMan chemistry from Life Technologies to detect pathogen specific gene sequences.
Test ID: #8003
Turn-around Time: 24-48 hours
Preferred Specimen: Vaginal swab
CPT Codes: 87081, 87150. MIC performed add charge 87186 or 87184
Billing Information: View Billing Information
Web Resources
  1. Mayo Clinic Staff (Updated 2012 February 25). Vagina: What's normal, what's not.
    http://www.mayoclinic.com/health/vagina/MY01913/METHOD=print through http://www.mayoclinic.com. Accessed March 2013.
  2. Gore, H. (Updated 2011 October 27). Vaginitis.
    http://emedicine.medscape.com/article/257141-overview through http://emedicine.medscape.com.
  3. Samra-Latif, O. (Updated 2012 January 13). Vulvovaginitis.
    http://emedicine.medscape.com/article/270872-overview through http://emedicine.medscape.com. Accessed March 2013.
  4. Leber, M. and Tirumani, A. (Updated 2012 April 16). Vulvovaginitis in Emergency Medicine.
    http://emedicine.medscape.com/article/797497-overview through http://emedicine.medscape.com. Accessed March 2013.
  5. CDC.
    Sexually transmitted diseases treatment guidelines. MMWR Recomm Rep 2010(https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5912a1.htm);59(No. RR-12).
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